BRG1 LOSS ATTENUATES ABERRANT WNT-SIGNALLING AND PREVENTS WNT-DEPENDENT TUMOURIGENESIS IN THE MURINE SMALL INTESTINE.

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.

Tumourigenesis bostik mvp within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling factor Brg1.We aimed to investigate this interdependency in an in vivo setting and assess the viability of Brg1 as a potential therapeutic target.Using a range of transgenic approaches

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